Search scope:
排序: Display mode:
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 747-757 doi: 10.1007/s11684-022-0954-x
Keywords: COVID-19 convalescent SARS-CoV-2 inactivated vaccination neutralizing antibody B cell response
Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 158-173 doi: 10.15302/J-FASE-2014015
Keywords: bovine Ig μ heavy-chain transgenic mice B cell development allelic exclusion immune response Ig repertoire
Frontiers of Medicine doi: 10.1007/s11684-023-0996-8
Keywords: BGB-A445 OX40 agonistic antibody OX40L noncompetitive
Passive antibody therapy in emerging infectious diseases
Frontiers of Medicine doi: 10.1007/s11684-023-1021-y
Keywords: SARS-CoV-2 COVID-19 convalescent plasma hyperimmunoglobulin neutralizing monoclonal antibodies
Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT
Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2, Pages 216-223 doi: 10.1007/s11705-012-1289-y
Keywords: recombinant protein polyclonal antibody label-free biosensor impedance white spot syndrome virus (WSSV
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 83-93 doi: 10.1007/s11684-019-0682-z
Keywords: S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy
Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA
Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3, Pages 409-416 doi: 10.1007/s11783-011-0349-8
Keywords: cadmium hapten monoclonal antibody enzyme-linked immunosorbent assay (ELISA)
Li Liu, Heng-Gui Chen, Ying Li, Huijun Li, Jiaoyuan Li, Yi Wang, Shuang Yao, Chuan Qin, Shutao Tong, Xu Yuan, Xia Luo, Xiaoping Miao , An Pan, Zheng Liu, Liming Cheng
Engineering 2021, Volume 7, Issue 7, Pages 958-965 doi: 10.1016/j.eng.2021.04.015
Keywords: Coronavirus disease 2019 Antibody response Cytokine Mortality Viral load
Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao
Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 204-211 doi: 10.1007/s11684-016-0443-1
Keywords: CD176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis
Modified Therapeutic Antibodies: Improving Efficacy Review
Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen
Engineering 2021, Volume 7, Issue 11, Pages 1529-1540 doi: 10.1016/j.eng.2020.06.030
Keywords: Therapeutic antibody Modification Efficacy Antigen Antibody–drug conjugate Bispecific antibody
Optimal Antibody Purification Strategies Using Data-Driven Models Article
Songsong Liu, Lazaros G. Papageorgiou
Engineering 2019, Volume 5, Issue 6, Pages 1077-1092 doi: 10.1016/j.eng.2019.10.011
This work addresses the multiscale optimization of the purification processes of antibody fragmentsnonlinear programming (MINLP) models are proposed to minimize the total cost of goods per gram of the antibody
Keywords: Antibody purification Multiscale optimization Antigen-binding fragment Mixed-integer programming
Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer
Engineering 2023, Volume 26, Issue 7, Pages 32-43 doi: 10.1016/j.eng.2022.08.016
Aberrant glycosylation is considered to be a hallmark of colorectal cancer (CRC), as demonstrated by various studies. While the N-glycosylation of cell lines and serum has been widely examined, the analysis of cancer-associated N-glycans from tissues has been hampered by the heterogeneity of tumors and the complexity of N-glycan structures. To overcome these obstacles, we present a study using laser capture microdissection that makes it possible to largely deconvolute distinct N-glycomic signatures originating from different regions of heterogeneous tissues including cancerous, stromal, and healthy mucosa cells. N-glycan alditols were analyzed by means of porous graphitized carbon liquid chromatography-electrospray ionization tandem mass spectrometry, enabling the differentiation and structural characterization of isomeric species. In total, 116 N-glycans were identified that showed profound differences in expression among cancer, stroma, and normal mucosa. In comparison with healthy mucosa, the cancer cells showed an increase in α2-6 sialylation and monoantennary N-glycans, as well as a decrease in bisected N-glycans. Moreover, specific sialylated and (sialyl-)LewisA/X antigen-carrying N-glycans were exclusively expressed in cancers. In comparison with cancer, the stroma showed lower levels of oligomannosidic and monoantennary N-glycans, LewisA/X epitopes, and sulfation, as well as increased expression of (core-)fucosylation and α2-3 sialylation. Our study reveals the distinct N-glycomic profiles of different cell types in CRC tumor and control tissues, proving the necessity of their separate analysis for the discovery of cancer-associated glycans.
Keywords: Colorectal cancer Tumor Porous graphitized carbon liquid chromatography mass spectrometry N-glycomics Antibodyresponse
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 644-648 doi: 10.1007/s11684-021-0847-4
Keywords: neutralizing antibody antibody cocktail SARS-CoV-2 COVID-19 therapeutic strategy
A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method Article
Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng
Engineering 2021, Volume 7, Issue 11, Pages 1566-1576 doi: 10.1016/j.eng.2020.10.024
Keywords: HER2/erb-B2 Human antibody Computer-aided design
Development of a seismic design method based on response spectra for building structures
ZHOU Xiyuan, YU Ruifang
Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2, Pages 129-141 doi: 10.1007/s11709-007-0014-2
Keywords: generalization classical damping mode-superposition response calculation formula damping theory
Title Author Date Type Operation
Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination
Journal Article
Depletion of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin
Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO
Journal Article
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation
Journal Article
Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv
Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT
Journal Article
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Journal Article
Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples
Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA
Journal Article
Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective
Li Liu, Heng-Gui Chen, Ying Li, Huijun Li, Jiaoyuan Li, Yi Wang, Shuang Yao, Chuan Qin, Shutao Tong, Xu Yuan, Xia Luo, Xiaoping Miao , An Pan, Zheng Liu, Liming Cheng
Journal Article
CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells
Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao
Journal Article
Modified Therapeutic Antibodies: Improving Efficacy
Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen
Journal Article
Optimal Antibody Purification Strategies Using Data-Driven Models
Songsong Liu, Lazaros G. Papageorgiou
Journal Article
Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma, and Normal Colon Mucosa
Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer
Journal Article
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
Journal Article
A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method
Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng
Journal Article